| 04/07/25 | Wanderers FC | 0 - 0 | Defensor Sporting Montevideo | - | - | - | | D |
| 04/01/25 | Defensor Sporting Montevideo | 2 - 0 | Miramar Misiones FC | - | - | - | | W |
| 03/27/25 | Danubio FC | 1 - 1 | Defensor Sporting Montevideo | - | - | - | | D |
| 03/23/25 | Defensor Sporting Montevideo | 0 - 0 | Cerro Largo | - | - | - | | D |
| 03/16/25 | CA Juventud | 2 - 1 | Defensor Sporting Montevideo | - | - | - | | L |
| 03/07/25 | Defensor Sporting Montevideo | 0 - 1 | Liverpool URU | - | - | - | | L |
| 02/23/25 | Plaza Colonia | 1 - 2 | Defensor Sporting Montevideo | - | - | - | | W |
| 02/16/25 | Defensor Sporting Montevideo | 2 - 0 | Racing Club Montevideo | - | - | - | | W |
| 02/12/25 | Defensor Sporting Montevideo | 0 - 2 | Monagas SC | - | - | - | | L |
| 02/08/25 | CA River Plate | 0 - 1 | Defensor Sporting Montevideo | - | - | - | | W |
| 02/05/25 | Monagas SC | 2 - 0 | Defensor Sporting Montevideo | - | - | - | | L |
| 02/01/25 | Defensor Sporting Montevideo | 2 - 0 | Boston River | - | - | - | | W |
| 01/22/25 | Defensor Sporting Montevideo | 1 - 1 | Instituto AC Cordoba | - | - | - | | D |
| 01/19/25 | Defensor Sporting Montevideo | 2 - 5 | Independiente | - | - | - | | L |
| 01/16/25 | Defensor Sporting Montevideo | 2 - 3 | Gimnasia La Plata | - | - | - | | L |
| 12/06/24 | Nacional Montevideo | 2 - 2 | Defensor Sporting Montevideo | - | - | - | | D |
| 11/30/24 | Miramar Misiones FC | 0 - 0 | Defensor Sporting Montevideo | - | - | - | | D |
| 11/27/24 | Cerro Largo | 3 - 0 | Defensor Sporting Montevideo | - | - | - | | L |
| 11/22/24 | Boston River | 0 - 1 | Defensor Sporting Montevideo | - | - | - | | W |
| 11/17/24 | CA Penarol | 2 - 0 | Defensor Sporting Montevideo | - | - | - | | L |
| 11/14/24 | Defensor Sporting Montevideo | 3 - 0 | Club Atletico Progreso | - | - | - | | W |
| 10/31/24 | Defensor Sporting Montevideo | 6 - 0 | Ferro Carril | - | - | - | | W |
| 10/24/24 | Defensor Sporting Montevideo | 1 - 0 | Racing Club Montevideo | - | - | - | | W |
| 10/16/24 | CA River Plate | 0 - 1 | Defensor Sporting Montevideo | 3.25 | 3.30 | 2.00 | | W |
| 10/12/24 | Defensor Sporting Montevideo | 1 - 2 | Boston River | - | - | - | | L |
| 09/29/24 | Defensor Sporting Montevideo | 3 - 1 | Deportivo Maldonado | - | - | - | | W |
| 09/26/24 | Bella Vista Paysandu | 0 - 3 | Defensor Sporting Montevideo | - | - | - | | W |
| 08/18/24 | Defensor Sporting Montevideo | 1 - 2 | Rampla Juniors FC | 1.55 | 3.90 | 5.00 | | L |
| 07/27/24 | CA Penarol | 1 - 0 | Defensor Sporting Montevideo | 1.73 | 3.40 | 4.10 | | L |
| 07/14/24 | Centro Atletico Fenix | 1 - 2 | Defensor Sporting Montevideo | - | - | - | | W |
